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  Indian J Med Microbiol
 

Figure 2: The results of the meta-analysis, using forest plots, combing the three clinical studies for moderate or high perceived stress (left panel) and moderate or severe depression (right panel). The study by Adams et al.[31]combined stress and depression, so the data are repeated in both panels. The meta-analysis was performed using Comprehensive Meta-Analysis (Biostat Inc., NJ, USA). The relative weight of the contribution of each study is provided. For moderate or high perceived stress, study heterogeneity in the meta-analysis was evident because of the study by Adams et al.[31] For perceived stress, Cochrane's Q was 19.9; P < 0.001, I2 = 90.0, and Tau2 = 1.16 + 1.62 (SEM). Removing the study of Adams et al. minimized the possibility of heterogeneity with a Cochrane Q = 3.23, P = 0.072. For depression, Cochrane's Q was 19.0; P < 0.001, I2 = 89.5, and Tau2 = 1.9 + 2.5 (SEM). Removing the study of Adams et al.[31] eliminated the heterogeneity Q = 0.058, P = 0.8. SEM: Standard error of the mean

Figure 2: The results of the meta-analysis, using forest plots, combing the three clinical studies for moderate or high perceived stress (left panel) and moderate or severe depression (right panel). The study by Adams <i>et al</i>.<sup>[31]</sup>combined stress and depression, so the data are repeated in both panels. The meta-analysis was performed using Comprehensive Meta-Analysis (Biostat Inc., NJ, USA). The relative weight of the contribution of each study is provided. For moderate or high perceived stress, study heterogeneity in the meta-analysis was evident because of the study by Adams <i>et al</i>.<sup>[31]</sup> For perceived stress, Cochrane's Q was 19.9; <i>P</i> < 0.001, <i>I</i><sup>2</sup> = 90.0, and Tau<sup>2</sup> = 1.16 + 1.62 (SEM). Removing the study of Adams <i>et al</i>. minimized the possibility of heterogeneity with a Cochrane Q = 3.23, <i>P</i> = 0.072. For depression, Cochrane's Q was 19.0; <i>P</i> < 0.001, <i>I</i><sup>2</sup> = 89.5, and Tau<sup>2</sup> = 1.9 + 2.5 (SEM). Removing the study of Adams <i>et al</i>.<sup>[31]</sup> eliminated the heterogeneity Q = 0.058, <i>P</i> = 0.8. SEM: Standard error of the mean