Figure 2: AGEs, Oxidative stress and cardiovascular disorders. Cardiovascular disorders are significantly impacted by oxidative stress. Through increased ROS production in the heart, AGEs and their receptors, such as RAGE, can be seen as a key mechanism for escalating oxidative stress. However, severe oxidative stress can hasten the synthesis of AGEs, particularly CML, as well as AGEs, oxidative stress, and the negative consequences each of these has on the heart. The risk of cardiovascular illnesses can rise as a result of this vicious AGE-RAGE and oxidative stress cycle. AGE = Advanced glycation end product, RAGE = Receptor for advanced glycation end products, CML = Carboxymethyl lysine, ROS = Reactive oxygen species