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REVIEW ARTICLE
Year : 2022  |  Volume : 6  |  Issue : 1  |  Page : 3-9

Relationship between red meat metabolite trimethylamine N-oxide and cardiovascular disease


1 Department of Cardiovascular Sciences, University of Leicester, Leicester, England, United Kingdom
2 Department of Cardiovascular Sciences, University of Leicester, Leicester, England, United Kingdom; Cardiovascular Genetics Group, Shantou University Medical College, Shantou, China

Correspondence Address:
Prof. Shu Ye
Department of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Groby Road, Leicester LE3 9QP

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/hm.hm_8_21

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Many cardiovascular diseases (CVD) are caused by the interplay of lifestyle and genetic factors. Studies have suggested an association between red meat consumption and increased CVD risk. There is evidence indicating that trimethylamine N-oxide (TMAO), a metabolite of red meat and other animal-derived foodstuffs, promotes CVD. Here, we undertake an overview of some of the reported investigations of the relationship between TMAO and CVD and briefly discuss possible underlying mechanisms.


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